Publications
150. Chen Wu, Sandra Goodrow, Hao Chen, Mengyan Li*, Distinctive Biotransformation and Biodefluorination of 6:2 versus 5:3 Fluorotelomer Carboxylic Acids by Municipal Activated Sludge, 2024, Water Research, in press.
149. Matrika Bhattarai, Qi Wang, Tasleem Javaid, Akshayaa Venkataraghavan, Md Tanim-Al Hassan, Malcolm O’Neil, Li Tan, Hao Chen, and Ahmed Faik*, Streamlining enzyme assays of glycosyltransferases activity using in vitro GT-array (i-GT-ray) platform: Application to family GT37 fucosyltransferases, Journal of Biological Chemistry, 2024, 300, 105734.
148. Md. Tanim-Al- Hassan, Xingzhi Chen, Praneeth Ivan Joel FNU, Francis J. Osonga, Omowunmi A. Sadik, Mengyan Li, and Hao Chen*, Rapid Detection of Per- and Polyfluoroalkyl Substances (PFAS) Using Paper Spray-Based Mass Spectrometry, Journal of Hazardous Materials (impact factor 13.6), 2024, 465, 133366.
147. Yanmei Li, Diana M. Castañeda-Bagatella, Dhyeyi Kakkad, Yongling Ai, Hao Chen, Pier Alexandre Champagne*, Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate, Organic & Biomolecular Chemistry, 2023, 21, 9583-9590.
146. Theresa Gewering, Deepali Waghray, Kristian Parey, Hendrik Jung, Nghi N.B. Tran, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Gerhard Hummer, Ina L. Urbatsch, Arne Moeller*, Qinghai Zhang*, Tracing the substrate translocation mechanism in P-glycoprotein, eLife12:RP90174
145. Zhaoxiong Wan, Shupei Yu, Qi Wang, Chen Wang, Karthik Sambeath, Xiangshan Liu, Xue Liu, Hao Chen, Yuewei Zhang*, Far-red BODIPY-based Oxime Esters: Photo-uncaging and Drug Delivery, Journal of Materials Chemistry B, 2023, 11, 9889-9893.
144. Praneeth Ivan Joel FNU, Md. Tanim-Al-Hassan, Timothy Yaroshuk, Yongling Ai and Hao Chen*, Absolute Quantitation of Peptides and Proteins by Coulometric Mass Spectrometry After Derivatization, Int. J. Mass Spectrom., 2024, 495, 117153 (https://authors.elsevier.com/a/1i0cD4xT2vCyTc).
143. Shupei Yu, Ojasvita Reddy, Alperen Abaci, Yongling Ai, Yanmei Li, Hao Chen, Murat Guvendiran, Kevin Belfield, Yuanwei Zhang, Novel BODIPY-based photobase generators for photo-induced polymerization, ACS Applied Materials & Interfaces, 2023, 15, 45281–45289.
142. Aida López Ruiz, Mengyuan Xao, Asmitha Sathya, Nicole Piccininni, Guangliang Liu, Noshin Siddiq, Hao Chen, Kathleen McEnnis*, Influence of particle z-potential and experimental procedure on protein corona formation and multicomponent aggregation, AIChE, 2023;e18237.
141. Yucong Shen, Frank Y. Shih*, and Hao Chen, Drug Toxicity Prediction by Machine Learning Approaches, International Journal of Pattern Recognition and Artificial Intelligence, 2023, 37, 2351013.
140. Chun Wang, Qianqian Wang, Jintao Yu, Xinmeng Wang, Lijuan Wang, Bin Zhao, Lin Hao, Weihua Liu, Zhi Wang, Hao Chen, Qiuhua Wu*, Converting waste expanded polystyrene into higher-value-added hyper-crosslinked porous polymer for rapid and high-efficient adsorption of aflatoxins, Journal of Cleaner Production, 2023, 408, 137102.
139. Yongling Ai, Praneeth Ivan Joel FNU, Pengyi Zhao, Md Tanim-Al-Hassan, Arjun Sharma, Gracelynne Hao, Zhenghao Zhou, Hao Chen*, Development of Coulometric Mass Spectrometry for Absolute Chemical Quantitation, Encyclopedia of Analytical Chemistry, 2024, DOI: 10.1002/9780470027318.a9811.
138. Harsha P. Gunawardena,*, Yongling Ai, Jinshan Gao, Richard N. Zare and Hao Chen*, Rapid Characterization of Antibodies via Automated Flow Injection Coupled with Microdroplet Reactions and Native Mass Spectrometry, Anal. Chem., 2023, 95, 6, 3340–3348 (Supplementary Cover).
137. Huifang Yao, Edward C. Sherer, Mei Lu, James Small, Gary E. Martin, Yu-hong Lam, Qinghao Chen, Roy Helmy, Yong Liu*, and Hao Chen*, One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites, J. Org. Chem., 2022, 87, 15011–15021 (Supplementary Cover). https://doi.org/10.1021/acs.joc.2c01311
136. Yongling Ai, Harsha P. Gunawardena*, Xuanwen Li, Yong-Ick Yong, Howard D. Dewald, and Hao Chen*, Standard-Free Absolute Quantitation of Antibody Deamidation Degradation and Host Cell Proteins by Coulometric Mass Spectrometry, 2022, Anal. Chem., 2022, 94, 12490−12499.
135. Yongling Ai, Jeffrey Xu, Harsha P. Gunawardena*, Richard N. Zare, and Hao Chen*, Investigation of Tryptic Protein Digestion in Microdroplet and in Bulk Solution, J. Am. Soc. Mass Spectrom., 2022, 33, 1238–1249.
134. Chen Wu, Qi Wang, Hao Chen*, Mengyan Li*, Rapid Quantitative Analysis and Suspect Screening of Per-and Polyfluorinated Alkyl Substances (PFAS) in Aqueous Film-Forming Foams (AFFFs) and Municipal Wastewater Samples by Nano-ESI-HRMS, Water Research, 2022, 219, 118542.
133. Qi Wang, Zhijian Liu, Yong Liu*, and Hao Chen*, Absolute Quantitation of N-Nitrosamines by Coulometric Mass Spectrometry without Using Standards, J. Am. Soc. Mass Spectrom., 2022, 33, 875–884.
132. Zhaoxiong Wan,a Shupei Yu,a Qi Wang,a John Tobia,a Hao Chen,a Zhanjun Li,b Xuan Liu,c and Yuanwei Zhang*, A BODIPY-based far-red fluorescent probe for hypochlorous acid imaging, ChemPhotoChem. 2022, 6, e202100250.
131. Wen Zhang*, Qi Wang and Hao Chen, Challenges in Characterization of Nanoplastics in the Environment, Front. Environ. Sci. Eng., 2022, 16, 11.
130. Tara L. Pukala* and Hao Chen, Editorial: Technical and Methodological Advances in Proteomics Frontiers in Chemistry, 2021.
129. Kai-Yuan Chiu, Qi Wang, Harsha P. Gunawardena*, Michael Held, Ahmed Faik, and Hao Chen*, Desalting Paper Spay Mass Spectrometry (DPS-MS) for Rapid Detection of Glycans and Glycoconjugates, Int. J. Mass Spectrom. 2021, 469, 116688 (2021 IJMS Best Student Paper Award).
128. Rahman, Md.; Pyle, Daniel; Bisz, Elwira; Dziuk, Błażej; Ejsmont, Krzysztof; Lalancette, Roger; Wang, Qi; Chen, Hao; Szostak, Roman; Szostak, Michal*, Evaluation of Cyclic Amides as Activating Groups in N–C Bond Cross-Coupling: Discovery of N-Acyl-δ- Valerolactams as Effective Twisted Amide Precursors for Cross-Coupling Reactions, J. Org. Chem., 2021, 86, 10455–10466.
127. Yongling Ai, Pengyi Zhao, Praneeth Ivan Joel FNU and Hao Chen*, Absolute Quantitation of Tryptophan-Containing Peptides and Amyloid Beta Peptide Fragments by Coulometric Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2021, 32, 1771-1779.
126. Xiaoqin Zhong, Hao Chen, Richard N. Zare*, Ultrafast Enzymatic Digestion of Deoxyribonucleic Acid in Aqueous Microdroplets for Sequence Discrimination and Identification, QRB Discovery, 2021, 2:e4, 1–8.
125. Kai Luo, Hao Chen, Richard N. Zare*, Location of carbon-carbon double bonds in unsaturated lipids using microdroplet mass spectrometry, Analyst, 2021, 146, 2550-2558.
124. Teng Yuan, Qi Tang, Chuan Shan, Xiaohan Ye, Jin Wang, Pengyi Zhao, Lukasz Wojtas, Nicholas Hadler, Hao Chen, Xiaodong Shi*, Alkyne Trifunctionalization via Divergent Gold Catalysis: Combining p-Acid Activation, Vinyl-Gold Addition and Redox Catalysis, JACS, 2021, 143, 4074–4082.
123. Jia Li, Chengyuan Liu, Hao Chen, Richard N. Zare*, Accelerated oxidation of organic sulfides by microdroplet chemistry, Journal of Organic Chemistry, 2021, 86, 5011–5015.
122. Pengyi Zhao, Harsha Gunawardena*, Xiaoqin Zhong, Richard N. Zare*, and Hao Chen*, Microdroplet Ultrafast Reactions Speed Antibody Characterization, Anal. Chem., 2021, 93, 3997–4005.
121. Qi Wang, Qile Wang, Yuexiang Zhang, Yasmine M. Mohamed, Carlos Pacheco, Nan Zheng*, Richard N. Zare*, Hao Chen*, Electrocatalytic Redox Neutral [3+2] Annulation of N-Cyclopropylanilines and Alkenes, Chem. Sci. 2021, 12, 969 - 975.
120. Chengyuan Liu, Qi Wang, Brian E. Hivick, Yongling Ai, Pier Alexandre Champagne, Yang Pan*, and Hao Chen*, Capture of electrochemically-generated fleeting carbazolium radical ion and elucidation of carbazole dimerization mechanism by mass spectrometry, Anal. Chem., 2020, 92, 15291–15296 (a supplenmentary cover).
119. Q. Wang, M. Bhattarai, P. Zhao, T. Alnsour, M. Held,* A. Faik,* H. Chen,* Fast and Sensitive Detection of Oligosaccharides Using Desalting Paper Spray Mass Spectrometry (DPS-MS), J. Am. Soc. Mass Spectrom. 2020,31, 2226–2235.
118. Xiaowei Song, Hao Chen, Richard N. Zare*, Coulometry-Assisted Quantitation in Spray Ionization Mass Spectrometry, J. Mass Spectrom. 2021, 56, e4628.
117. Pengyi Zhao, Qi Wang, Manpreet Kaur, Yong-Ick Kim, Howard D. Dewald, Olivier Mozziconacci, Yong Liu, and Hao Chen*, Absolute Quantitation of Proteins by Coulometric Mass Spectrometry, Analytical Chemistry, 2020, 92, 7877–7883.
116. Xiaowei Song and Hao Chen*, Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) for Tissue Analysis, Encyclopedia of Analytical Chemistry, 2020, https://doi.org/10.1002/9780470027318.a9640.
115. Teng Yuan, Pengyi Zhao, Shun Teng, Yaping Yi, Jin Wang, Chuan Shan, Lukasz Wojtas, Jonathan Jean, Hao Chen*, Xiaodong Shi*, Regioselective Crossed Aldol Reactions under Ambient Conditions via Synergistic Gold/Iron Catalysis, Chem (Impact Factor 22.8, Cell Press), 2020, 6, 1420–1431.
114. M. Rahman, C. Liu, E. Bisz, B. Dziuk, R. Lalancette, Q. Wang, H. Chen, R. Szostak, M. Szostak,* N-Acyl-Glutarimides: Effect of Glutarimide Ring on the Structures of Fully Perpendicular Twisted Amides and N–C Bond Cross-Coupling, J. Org. Chem., 2020, 85, 5475–5485.
113. Jin Wang, Chiyu Wei, Xuming Li, Pengyi Zhao, Chuan Shan, Lukasz Wojtas, Hao Chen, Xiaodong Shi*, Gold Redox Catalysis with Selenium Cation as Mild Oxidant, Chem. Eur. J. 2020, 26, 5946-5950.
112. Kai Luo, Jia Li, Yufei Cao, Chengyuan Liu, Jun Ge, Hao Chen, Richard N. Zare*, Reaction of chloroauric acid with histidine in microdroplets yields catalytic Au-(His)2 complex, Chemical Science, 2020, 11, 2558.
111. Xiaoqin Zhong, Hao Chen, Richard N. Zare*, Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry, Nature Communications, 2020, 11:1049.
110. Karthik Sambath, Zhaoxiong Wan, Qi Wang, Hao Chen, Yuewei Zhang*, BODIPY-Based Photoacid Generators (PAGs) for Light-Induced Cationic Polymerization, Organic Letters, 2020, 22, 1208–1212.
109. Rahul Narayanan, Xiaowei Song, Hao Chen, Richard Zare,* Teflon Spray Ionization Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2020, 31, 234-239.
108. Chengyuan Liu, Jia Li, Hao Chen, and Richard N. Zare*, Scale-Up of Microdroplet Reactions by Heated Ultrasonic Nebulization, Chemical Science, 2019, 10, 9367-9373.
107. Xiaohan Ye,‡ Pengyi Zhao,‡ Shuyao Zhang, Yanbin Zhang, Qilin Wang, Chuan Shan, Lukasz Wojtas, Hao Guo*, Hao Chen*, and Xiaodong Shi,* Facilitating Gold Redox Catalysis with Electrochemistry: An Efficient “Chemical-Oxidant-Free” Approach (Hot paper, ‡ equal contribution), Angew. Chem. Int. Ed., 2019, 58, 17226 –17230.
106. Pengyi Zhao, Richard N. Zare*, Hao Chen*, Absolute Quantitation of Oxidizable Peptides Using Coulometric Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2019, 30, 2398-2407.
105. Pengyi Zhao, Yong Guo*, Howard D. Dewald*, and Hao Chen*, Improvements for Absolute Quantitation Using Electrochemical Mass Spectrometry, Int. J. Mass Spectrom. 2019, 443, 41-45.
104. Chang Xu, Qiuling Zheng, Pengyi Zhao, Joseph Paterson, Hao Chen*, A New Quantification Method Using Electrochemical Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2019, 30, 685–693.
103. X. Song, H. Chen, R. N. Zare*, Conductive Polymer Spray Ionization Mass Spectrometry for Biofluid Analysis, Anal. Chem., 2018, 90, 12878–12885.
102. P. Zhao, T. White, R. Graham Cooks,* Q. Chen,* Yong Liu and H. Chen*, “Detection of Neutral Species CO Lost During Ionic Dissociation Using Atmospheric Pressure Thermal Dissociation Mass Spectrometry (APTD-MS)", J. Am. Soc. Mass Spectrom. 2018, 29, 2317-2326.
101. Zhengzheng Chen, Zhongyao Jiang, Fanpeng Kong, Hao Chen, Bo Tang*, “Target Discovery of Ebselen with a Biotinylated Probe”, Chem. Commun., 2018, 54, 9506-9509.
100. Qiuling Zheng, Yang Tian, Xujun Ruan, Hao Chen, Xunxun Wu, Xiaowei Xu, Haiping Hao*, Hui Ye*, “Probing Specific Ligand-Protein Interactions by Native-Denaturing Switchable Desorption Electrospray Ionization Mass Spectrometry", Analytica Chimica Acta, 2018,1036,58-65.
99. Jin Wang, Shuyao Zhang, Chang Xu, Lukasz Wojtas, Novruz G. Akhmedov, Hao Chen, Xiaodong Shi,* “Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need of a Strong Oxidant”, Angew. Chem. Int. Ed., 2018, 57, 6915 –6920.
98. Michael Nshanian, Rajeswari Lakshmanan, Hao Chen, Rachel Loo*, Joseph Loo*, “Enhancing Sensitivity of Liquid Chromatography/Mass Spectrometry of Peptides and Proteins Using Supercharging Agents”, Int. J. Mass Spec. 2018, 427, 157-164.
97. Mei Lu, Yijin Su, Pengyi Zhao, Xiaohan Ye, Yi Cai, Xiaodong Shi,* Eric Masson,* Fengyao Li, J. Larry Campbell and Hao Chen*, “Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry”, Chemistry - A European Journal, 2018, 24, 2144-2150.
96. Yi Cai, Jiang Wang, Yuexiang Zhang, Zhi Li, David Hu, Nan Zheng*, and Hao Chen*, “Detection of Fleeting Amine Radical Cations and Elucidation of Chain Processes in Visible Light-Mediated [3+2] Annulation by Online Mass Spectrometric Techniques”, J. Am. Chem. Soc., 2017, 139, 12259–12266.
95. Pengyuan Liu, Pengyi Zhao, R. Graham Cooks* and Hao Chen*, “Atmospheric Pressure Neutral Reionization Mass Spectrometry for Structural Analysis”, Chemical Science, 2017, 8, 6499-6507.
94. Si Cheng, Qiuhua Wu*, He Xiao, and Hao Chen*, “Online Monitoring of Enzymatic Reactions Using Time-Resolved Desorption Electrospray Ionization Mass Spectrometry”, Anal. Chem., 2017, 89, 2338–2344.
93. Qiuhua Wu*, Si Cheng, Hao Chen and Chun Wang*, “ZIF-67 templated synthesis of nanoporous carbon as an efficient adsorbent for preconcentration of flunitrazepam from beverage samples”, Food Anal. Methods, 2017, 10, 2772–2780.
92. Zhi Li*, Shuaihua Zhang, Yi Cai, Qiuhua Wu, Hao Chen*, “Hollow fiber-based solid-liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine”, Anal. Methods, 2016, 8, 7800-7807.
91. Qiuhua Wu*, Si Cheng, Chenhuan Wang, Xiyang Li, Zhi Li, Hao Chen*, "Magnetic porous carbon derived from bimetallic metal-organic framework: A novel magnetic solid phase extraction adsorbent for flunitrazepam", Microchimica Acta, 2016, 183, 3009-3017.
90. Xiaohan Ye, Chang Xu, Lukasz Wojtas, Novruz Akhmedov, Hao Chen*, Xiaodong Shi* “Silver-Free Palladium Catalyzed sp3 and sp2 C-H Alkynylation Promoted by 1,2,3-Triazole Amine (TAM) Directing Group", Org. Lett., 2016, 18, 2970–2973.
89. Haihui Peng, Rong Cai, Chang Xu, Hao Chen*, and Xiaodong Shi*, “Nucleophile Promoted Gold Redox Catalysis with diazonium: C-Br, C-S and C-P Bond Formation through Catalytic Sandmeyer Coupling”, Chemical Science, 2016, 7, 6190–6196.
88. Si Cheng, Qiuhua Wu, Howard D. Dewald*, and Hao Chen*, “Online Monitoring of Methanol Electro-Oxidation Reactions by Ambient Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 2017, 28, 1005–1012.
87. Qiuhua Wu*, Si Cheng, Zhi Li and Hao Chen*, “Highly sensitive mass spectrometric detection of flunitrazepam using magnetic graphene framework enrichment”, Analytical Methods, 2016, 8, 6168 - 6175.
86. Yi Cai, Pengyuan Liu, Michael Held, Howard Dewald, Hao Chen*, “Coupling Electrochemistry with Probe Electrospray Ionization Mass Spectrometry (PESI-MS)", ChemPhysChem, 2016, 17, 1104-1109.
85. Qiuling Zheng, Hao Chen*, “Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (LS-DESI-MS)” Annual Reviews in Analytical Chemistry, 2016, 9, 411–448.
84. Qiuling Zheng, Hao Zhang, Shiyong Wu and Hao Chen*, “Probing Protein Three-Dimensional Structures and Conformational Changes Using Electrochemistry-Assisted Isotope Labeling Cross-Linking Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 2016, 27, 864-875.
83. Timothy A. Brown, Niloufar Hosseinei-Nassab, Hao Chen*, and Richard N. Zare*, Observation of Electrochemically Generated Nitrenium Ions by Desorption Electrospray Ionization Mass Spectrometry, Chemical Science, 2016, 7, 329.
82. Qiuling Zheng, Yong Liu*, Qinghao Chen*, MeiHong Hu, Roy Helmy, Edward C. Sherer, Christopher J. Welch, and Hao Chen*, "Capture of Reactive Monophosphine Ligated Palladium(0) Intermediates by Mass Spectrometry", J. Am. Chem. Soc., 2015, 137, 14035-14038.
81. Si Cheng, Jun Wang,* Yi Cai, Joseph A. Loo,* and Hao Chen*, Enhancing Performance of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry Using Trap and Capillary Columns, Int. J. Mass Spectrom. 2015, 392, 73-79.
80. Timothy A. Brown, Hao Chen*, and Richard N. Zare*, “Mass Spectrometric Detection of the Short-Lived Radical Cation Intermediate in the Electrooxidation of N,N-Dimethylaniline”, Angew. Chem. Int. Ed., 2015, 54, 11183 –11185 (VIP paper).
79. Rong Cai, Mei Lu, Ellen Aguilera, Yumeng Xi, Novruz Akhmedov, Jeffrey Petersen, Hao Chen*, Xiaodong Shi*, Ligand-Assisted Gold-Catalyzed Cross-Coupling with Aryldiazonium Salts: A Case of External Oxidant Free Redox Gold Catalysis, Angew. Chem. Int. Ed., 2015, 54, 8772 –8776 (Hot Paper).
78. Lu Li, Xiuli Wang, Qingling Li, Pengyuan Liu, Kehua Xu, Hao Chen*, Bo Tang*, An Accurate Mass Spectrometric Approach for Simultaneous Comparison of GSH, Cys, and Hcy in L02 and HepG2 Cells Using New NPSP Isotope Probes", Chem. Commun. 2015, 51, 11317.
77. Mei Lu, Yong Liu*, Roy Helmy, Gary E. Martin, Howard D. Dewald, and Hao Chen*, Investigation of Aqueous Phase Electrochemical Reactions by Desorption Electrospray Ionization Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2015, 26, 1676-1685.
76. Timothy A. Brown, Hao Chen*, and Richard N. Zare*, Mass Spectrometric Identification of Fleeting Electrochemical Reaction Intermediates, (JACS spotlight) J. Am. Chem. Soc. 2015, 137, 7274−7277.
75. Pengyuan Liu, Qiuling Zheng, Howard D. Dewald, Rebecca Zhou and Hao Chen*, “The study of electrochemistry with ambient ionization methods”, Trends in Analytical Chemistry, 2015, 70, 20–30.
74. Yi Cai, Qiuling Zheng, Yong Liu, Roy Helmy, Joseph A. Loo and Hao Chen*, Integration of Electrochemistry with Ultra Performance Liquid Chromatography/Mass Spectrometry (UPLC/MS), Eur. J. Mass Spectrom. 2015, 21, 341–351.
73. Fanpeng Kong, Bo Hu, Yan Gao, Kehua Xu*, Xiaohong Pan, Fang Huang, Qiuling Zheng, Hao Chen, Bo Tang*; “Fluorescence Imaging for Selenol in HepG2 Cell Apoptosis Induced by Na2SeO3”, Chem. Commun. 2015, 51, 3102-3105.
72. Pengyuan Liu, R. G. Cooks*, and, Hao Chen*. “Nuclear Magnetic Resonance Structure Elucidation of Peptide b2 Ions”, Angew. Chem. Int. Ed., 2015, 54, 1547–1550.
71. Qiuling Zheng, Hao Zhang*, Lingying Tong, Shiyong Wu, and Hao Chen*, A New Cross-Linking Electrochemical Mass Spectrometry for Probing Protein 3D-Structures”, Anal. Chem. 2014, 86, 8983-8991.
70. Yi Cai, Yong Liu, Roy Hemly and Hao Chen*, “Coupling of Ultrafast LC Separation with Mass Spectrometry by DESI", J. Am. Soc. Mass Spectrom. 2014, 25, 1820-1823.
69. Pengyuan Liu, Amanda Forni, Hao Chen*, “Development of Solvent-Free Ambient Mass Spectrometry for Green Chemistry Applications", Anal. Chem., 2014, 86, 4024-4032.
68. Yi Cai, Daniel Adams and Hao Chen*, A New Splitting Method for Both Analytical and Preparative LC/MS, J. Am. Soc. Mass Spectrom. 2014, 25, 286-292.
67. Yijin Su, Mei Lu, Boliang Dong, Hao Chen,* Xiaodong Shi,* “Silver Catalyzed Alkyne Activation: the Surprising Ligand Effect”, Advanced Synthesis & Catalysis, 2014, 356, 692-696.
66. Pengyuan Liu, Jiang Zhang, Carly N. Ferguson, Hao Chen,* Joseph A. Loo,* “Measuring Protein-Ligand Interactions Using Liquid Sample Desorption Electrospray Ionization Mass Spectrometry”, Anal. Chem. 2013, 85, 11966−11972.
65. Pengyuan Liu, Mei Lu, Qiuling Zheng, Howard D. Dewald, Yun Zhang and Hao Chen*, “Recent Advances in Electrochemical Mass Spectrometry”, Analyst, 2013, 138, 5519–5539.
64. Qiuling Zheng, Hao Zhang* and Hao Chen*, “Integration of Online Digestion and Electrolytic Reduction with Mass Spectrometry for Rapid Disulfide-Containing Protein Structural Analysis”, Int. J. Mass Spectrom. 2013, 353, 84-92.
63. Ismael Cotte-Rodriguez, Yun Zhang, Zhixin Miao and Hao Chen*, “Introduction to Protein Mass Spectrometry”, Characterization of Protein Therapeutics using Mass Spectrometry, Guodong Chen, Ed., Springer Science+Business Media New York, 2013, in press.
62. Ning Pan, Pengyuan Liu, Hao Chen*, Weidong Cui, Bo Tang and Jingmin Shi, "Highly Efficient Ionization of Phosphopeptides by Desorption Electrospray Ionization Mass Spectrometry", Analyst, 2013, 138, 1321-1324.
61. Mei Lu, J. Larry Campbell*, Rajat Chauhan, Craig A. Grapperhaus*, and Hao Chen*, “Probing the Reactivity and Radical Nature of Oxidized Transition Metal-Thiolate Complexes by Mass Spectrometry”, The Special Issue of Distonic Ions, J. Am. Soc. Mass Spectrom. 2013, 24, 502-512.
60. Effie Weldy, Chloe Wolff, Zhixin Miao, Hao Chen*, “Selective and Sensitive Detection of Chromium (VI) in Waters Using Electrospray Ionization Mass Spectrometry”, Science & Justice, 2013, 53, 293-300.
59. Yan Liu, Zhixin Miao, Rajeswari Lakshmanan, Rachel R. Ogorzalek Loo, Joseph A. Loo and Hao Chen*, Signal and Charge Enhancement for Protein Analysis by Liquid Chromatography-Mass Spectrometry with Desorption Electrospray Ionization, Eugene Nikolaev Honor Issue, Int. J. Mass Spectrom. 2012, 325-327, 161-166.
58. Pengyuan Liu, Ingela T. Lanekoff, Julia Laskin*, Howard D. Dewald and Hao Chen*, The Study of Electrochemical Reactions Using Nanospray Desorption Electrospray Ionization-Mass Spectrometry, Anal. Chem. 2012, 84, 5737−5743.
57. Zhenzhen Chen, Qingling Li, Qianqian Sun, Hao Chen, Xu Wang, Na Li, Miao Yin, Yanxia Xie, Hongmin Li, and Bo Tang*, Simultaneous Determination of Reactive Oxygen and Nitrogen Species in Mitochondrial Compartments of Apoptotic HepG2 Cells and PC12 Cells Based On Microchip Electrophoresis−Laser-Induced Fluorescence, Anal. Chem. 2012, 84, 4687–4694.
56. Yun Zhang, Weidong Cui, Hao Zhang, Howard D. Dewald and Hao Chen*, Electrochemistry-Assisted Top-Down Characterization of Disulfide-Containing Proteins. Anal. Chem. 2012, 84, 3838–3842.
55. Zhengfang Wang, Yun Zhang, Hao Zhang, Peter B. Harrington*, and Hao Chen*, Fast and Selective Modification of Thiol Proteins/Peptides by N-(Phenylseleno)phthalimide. J. Am. Soc. Mass Spectrom., 2012, 23, 520-529.
54. Mei Lu, Chloe Wolff, Weidong Cui, and Hao Chen*, Investigation of Some Biologically Relevant Redox Reactions Using Electrochemical Mass Spectrometry Interfaced by Desorption Electrospray Ionization Anal. Bioanal. Chem., 2012, 403, 355-365
53. Carly Ferguson, Sabrina Benchaar, Zhixin Miao, Joseph Loo*, and Hao Chen*, Direct Ionization of Large Proteins and Protein Complexes by Desorption Electrospray Ionization-Mass Spectrometry, Anal. Chem. 2011, 83, 6468-6473 (accelerated article; highlighted by Chemical & Engineering News).
52. Paul D'Aloise, Hao Chen*, Rapid Determination of Flunitrazepam in Alcoholic Beverages by Desorption Electrospray Ionization-Mass Spectrometry, Science & Justices, 2012, 52, 2-8.
51. Yun Zhang, Hao Zhang, Weidong Cui and Hao Chen*, Tandem MS Analysis of Selenamide-Derivatized Peptide Ions, J. Am. Soc. Mass Spectrom., 2011, 22, 1610-1621.
50. Zhixin Miao, Hao Chen*, Pengyuan Liu, Yan Liu, Development of Submillisecond Time-Resolved Mass Spectrometry Using Desorption Electrospray Ionization. Anal. Chem. 2011, 83, 3994-3997.
49. Yun Zhang, Zongqian Yuan, Howard D. Dewald and Hao Chen*, Coupling of Liquid Chromatography with Mass Spectrometry by Desorption Electrospray Ionization. Chem. Comm. 2011, 47, 4171 – 4173.
48. Yun Zhang, Howard D. Dewald and Hao Chen*, On-Line Mass Spectrometric Analysis of Proteins/Peptides Following Electrolytic Reduction of Disulfide Bonds. J. Proteome Res. 2011, 10, 1293-1304.
47. Xiaobo Sun, Zhixin Miao, Zongqian Yuan, Peter B. Harrington*, Jennifer Colla and Hao Chen*, “Coupling of Single-Droplet Microextraction with Desorption Electrospray Ionization Mass Spectrometry”, Int. J. Mass Spectrom. 2011, 301,102–10.
46. Ismael Cotte-Rodriguez, Yun Zhang, Zhixin Miao and Hao Chen*, “Ionization Methods in Protein Mass Spectrometry”, Protein Mass Spectrometry, Guodong Chen, et al. Ed., John Wiley & Sons, 2011, pp 3-42.
45. Brian Gau, Hao Chen, Yun Zhang and Michael Gross*, “Fast Photochemical-Initiated Modification of Proteins by Sulfate Radical Anion Probes Solvent Accessibility” Anal. Chem. 2010, 82, 7821–7827.
44. Kehua Xu, Yun Zhang, Bo Tang*, Julia Laskin, Patrick J. Roach and Hao Chen*, “The Study of Highly Selective Thiol Derivatization using Selenium Reagents by Mass Spectrometry”, Anal. Chem. 2010, 82, 6926–6932.
43. Zhixin Miao, Shiyong Wu and Hao Chen*, “Probing Protein Conformation by Desorption Electrospray Ionization Mass Spectrometry”, J. Am. Soc. Mass Spectrom. 2010, 21, 1730-1736 (Won the 2012 Ron Hites Award for Outstanding Research Publication in JASMS).
42. Hao Chen*, Review on the book "Mass Spectrometry Instrumentation, Interpretation, and Applications" (ISBN 978-0-471-71395-1), J. Am. Soc. Mass Spectrom., 2010, 21, R1.
41. Yun Zhang and Hao Chen*, “In-Situ Selective and Sensitive Detection of Monosaccharides by Reactive Desorption Electrospary Ionization (DESI) using Modified Phenylboronic Acids”, Int. J. Mass Spectrom., 2010, 289, 98 -107.
40. Hao Chen and Jiwen Li, “Rapid Analysis of Drug Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry”, in Characterization of impurities and degradants using mass spectrometry, Guodong Chen Ed., John Wiley & Sons, 2010, pp 81-108.
39. Jiwen Li, Howard Dewald and Hao Chen*, “On-line Coupling of Electrochemical Reactions with Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)”, Anal. Chem., 2009, 81, 9716-9722.
38. Wei Lu, Csaba F. László, Zhixin Miao, Hao Chen and Shiyong Wu*, "The Role of Nitric Oxide Synthase in the Regulation of Ultraviolet Light-induced Phosphorylation of the Alpha-subunit of Eukaryotic Initiation Factor 2", J. Biol. Chem., 2009, 284, 24281-24288.
37. Hao Chen, “Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry: From the Gas Phase to Solution”, in MS Investigations of Reactive Intermediates in Solution, Leonardo S. Santos Ed., Wiley-VCH, 2009, pp 37-62.
36. Zhixin Miao and Hao Chen*, "Direct Analysis of Liquid Samples by Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS)", J. Am. Soc. Mass Spectrom, 2009, 20, 10-19. (Top ten most-cited articles in the Journal of American Society for Mass Spectrometry from 2008-2013).
35. Wen-Ping Peng, Mike Goodwin, Hao Chen, R. Graham Cooks*, Jonathan Wilker, "Thermal Formation of Mixed-Metal Inorganic Complexes at Atmospheric Pressure", 2008, Rapid Commun. Mass Spectrom. 2008, 22, 3540.
34. Livia S. Eberlin, Yu Xia, Hao Chen and R. Graham Cooks*, "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides", J. Am. Soc. Mass Spectrom., 2008, 19, 1897–1905.
33. Hao Chen, Livia S. Eberlin, Marcela Nefliu, Rodinei Augusti and R. Graham Cooks*, "Organic Reactions of Ionic Intermediates Promoted by Atmospheric Pressure Thermal Activation", Angew. Chem. Int. Ed., 2008, 47, 3422-3425.
32. Ismael Cotte-Rodriguez, Heriberto Hernández-Soto, Hao Chen, R. Graham Cooks*, "In-situ Trace Detection of Peroxide Explosives by Complexation during Desorption Electrospray Ionization and Desorption Atmospheric Pressure Chemical Ionization", Anal. Chem., 2008, 80, 1512-1519.
31. Guangming Huang, Hao Chen, Xinrong Zhang, R. Graham Cooks* and Zheng Ouyang*, “Rapid Screening of Anabolic Steroids in Urine by Reactive Desorption Electrospray Ionization”, Anal. Chem., 2007, 79, 8327-8332.
30. Hao Chen, Livia S. Eberlin, R. Graham Cooks*, "Neutral Fragment Mass Spectra via Ambient Thermal Dissociation of Peptide/Protein Ions", J. Am. Chem. Soc., 2007, 129, 5880-5886 (highlighted by J. Proteome Res.).
29. Hao Chen, Zheng Ouyang, R. Graham Cooks*, "Thermal Production and Reactions of Organic Ions at Atmospheric Pressure", Angew. Chem. Int. Ed., 2006, 3656-3660 (VIP).
28. R. Graham Cooks*, Hao Chen, Marcos N. Eberlin, Xubin Zheng and W. Andy Tao, “Polar Acetalization and Transacetalization in the Gas Phase: The Eberlin Reaction”, Chem. Rev. 2006, 106, 188-211.
27. Hao Chen, Ismael Cotte-Rodriguez and R. Graham Cooks*, “cis-Diol Functional Group Recognition by Reactive Desorption Electrospray Ionization”, Chem. Commun. 2006, 597-599 (hot article & front cover).
26. Ismael Cotte-Rodriguez, Hao Chen and R. Graham Cooks*, “Rapid Trace Detection of Triacetone Triperoxide (TATP) by Complexation Reactions during Desorption Electrospray Ionization”, Chem. Commun. 2006, 953-955 (hot article, front cover & top 10 articles in February issue; also featured in Chemical & Engineering News).
25. Rodinei Augusti, Hao Chen, Livia Schiavinato Eberlin, Marcela Nefliub and R. Graham Cooks, “Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous liquid/gas phase”, Int. J. Mass Spectrom., 2006, 253, 281-287.
24. Daniel J. Goebbert, Hao Chen and Paul G. Wenthold*, “Collision-Induced Dissociation Studies of Protonated Ether–(H2O)n (n=1–3) Clusters”, J. Mass Spectrom. 2006, 41, 242–247.
23. Hao Chen, Dina R. Justes and R. Graham Cooks*, “Proton Affinities of N-Heterocyclic Carbene Super Bases”, Org. Lett. 2005, 7, 3949-3952.
22. Hao Chen, R. Graham Cooks*, Eduardo C. Meurer and Marcos N. Eberlin, “Hydrogen/Chlorine Exchange Reactions of Gaseous Carbanions”, J. Am. Soc. Mass Spectrom. 2005, 2045-2051.
21. Igor A. Popov, Hao Chen, Oleg N. Kharybin, Eugene N. Nikolaev and R. Graham Cooks*, “Detection of Explosives on Solid Surfaces by Thermal Desorption and Ambient Ion/Molecule Reactions”, Chem. Commun., 2005, 1953-1955.
20. Yishu Song, Hao Chen and R. Graham Cooks*, “Reactivity of Acetonyl Anion with Nitroaromatics: An Atmospheric Pressure Chemical Ionization Study”, Rapid Commun. Mass Spectrom. 2005, 19, 3493-3499.
19. Huanwen Chen, Ruifeng Xu, Hao Chen, R. Graham Cooks* and Zheng Ouyang, "Ion/Molecule Reactions in a Miniature RIT Mass Spectrometer", J. Mass Spectrom., 2005, 40, 1403-1411.
18. Hao Chen, Xubin Zheng, Pengxiang Yang and R. Graham Cooks*, “Reduction of Nitroaromatics to Arylnitrenium Ions by Vinyl Halide Cations” Chem. Commun., 2004, 688-689.
17. Hao Chen, Huanwen Chen and R. Graham Cooks*, “Generation of Arylnitrenium Ions by Nitro-reduction and Gas-Phase Synthesis of N-Heterocycles” J. Am. Soc. Mass Spectrom., 2004, 15, 1675-1688.
16. Hao Chen, Huanwen Chen and R. Graham Cooks*, "Meisenheimer Complexes Bonded at Carbon and at Oxygen in the Gas Phase", J. Am. Soc. Mass Spectrom., 2004, 15, 998-1004.
15. Eduardo C. Meurer, Hao Chen, Leah Riter, Ismael Cotte-Rodriguez, Marcos N. Eberlin and R. Graham Cooks*, “Gas-Phase Reactions for Selective Detection of the Explosives TNT and RDX” Chem. Commun., 2004, 40-41.
14. Eduardo C. Meurer, Hao Chen, Leah S. Riter, Marcos N. Eberlin and R. Graham Cooks*, "Meerwein Reaction of Phosphonium Ions with Epoxides and Thioepoxides in the Gas Phase," J. Am. Soc. Mass Spectrom., 2004, 15, 398-405.
13. Rodinei Augusti, Daniella V. Augusti, Hao Chen, and R. Graham Cooks*, “Gas-Phase Halide Affinity of Aliphatic Alcohols Estimated by the Kinetic Method” Eur. J. Mass Spectrom., 2004, 10, 847.
12. Rodinei Augusti, Maciej Turowski, Hao Chen and R. Graham Cooks*, " Dissociation of Ionized Benzophenones Investigated by the Kinetic Method: Effective Temperature, Steric Effects, and Gas-Phase CO+• Affinities of Phenyl Radicals” J. Mass Spectrom., 2004, 39, 558-564.
11. Habib Bagheri, Hao Chen and R. Graham Cooks*, “Chiral Recognition by Proton Transfer Reactions with Optically Active Amines and Alcohols” Chem. Commun., 2004, 2740-2741.
10. Hao Chen, Xubin Zheng and R. Graham Cooks*, “Ketalization of Phosphonium Ions by 1, 4-Dioxane: Selective Detection of the Chemical Warfare Agent Simulant DMMP in Mixtures Using Ion/Molecule Reactions” J. Am. Soc. Mass Spectrom., 2003, 14, 182–188.
9. Leah S. Riter, Eduardo C. Meurer, Eric S. Handberg, Brian C. Laughlin, Hao Chen, Garth E. Patterson and R. Graham Cooks*, “Ion /Molecule Reactions Performed in a Miniature Cylindrical Ion Trap Mass Spectrometer”, Analyst, 2003, 28, 1112-1118 (front cover).
8. Hao Chen and Yuegang Zuo*, “Identification of Flavonol Glycosides in American Cranberry Fruit”, Food Chem. 2007, 101, 1357.
7. Yiwei Deng*, Kai Zhang, Hao Chen, Taixing Wu, Metthew Krzyaniak, Amina Wellons, Dawn Bolla, Kenneth Douglas, Yuegang Zuo, "Iron-catalyzed photochemical transformation of benzoic acid in atmospheric liquids: Product identification and reaction mechanisms", Atmos. Environ., 2006, 40, 3665-3676.
6. Yuegang Zuo* and Hao Chen, “Determination of Sulfite, Sulfate and Hydroxymethanesulfonate in Atmospheric Water by Ion-Pair HPLC Technique” Talanta, 2003, 59, 875-881.
5. Yuegang Zuo*, Hao Chen and Yiwei Deng, “Simultaneous Determination of Catechins, Phenolic Acids and Caffeine in Green, Oolong, Black and Pu-erh Teas Using HPLC with a Photodiode Array Detector” Talanta, 2002, 57, 307-316.
4. Hao Chen, Yuegang Zuo*, and Yiwei Deng, “Separation and Determination of Flavonoids and Other Phenolic Compounds in Cranberry Juice by HPLC” J. Chromator., A, 2001, 913, 387-395.
3. Yonggang Yang, Hao Chen, Geng Tang and Jianxun Wen*, “Synthesis and Mesomorphic Properties of Some Fluorinated Benzoate Liquid Crystals” Mol. Cryst. Liq. Cryst., 2002, 373, 1-15.
2. Yonggang Yang, Hao Chen, Geng Tang and Jianxun Wen*, “Synthesis and Mesomorphic Properties of Several Series of Fluorinated Ester Liquid Crystals” Liq. Cryst., 2002, 29, 255-261.
1. Jianxun Wen, Hao Chen and Yuehai Shen*, “The First Series of Ferroelectric Steroidal Fluorinated Liquid Crystals” Liq. Cryst., 1999, 26, 1833-1834.